In 1905, a team of Waseda University students visited the United States and conducted a tour in which it played American baseball teams up and down the West coast. One of those games, on May 17th, was against Los Angeles High School, which Waseda won 5-3. According to some sources, this was the first game of a tour that included games in San Francisco, Palo Alto, Los Angeles, Bakersfield, Fresno, Eugene, Oregon, and Seattle (other sources cite a start date from April of that year). Regardless, the tour marked the first time that a Japanese team played baseball in the United States.
The first game between an American and a Japanese professional baseball team was played on November 22, 1908. In the game, the Reach All-Americans defeated Waseda University in Tokyo, 5-0.