At the age of seventeen, Chattanooga Lookouts pitcher Jackie Mitchell struck out both Babe Ruth and Lou Gehrig in an exhibition game on April 2, 1931. After taking a ball, Ruth swung and missed at the next two pitches, and then Mitchell’s fourth pitch to Ruth was a called third strike. Gehrig then swung through the first three pitches to strike out.
Mitchell was one of the first female pitchers in professional baseball history. Shortly after the exhibition game, Commissioner Kenesaw Mountain Landis voided her contract and forbid the signing of women.